Side effects and complications in the use of drugs: androgenic phenomenon - the appearance of acne, weight gain, increased appetite, seborrhea, hirsutism, hair loss, change of voice, clitoris hypertrophy, fluid retention in the body, menstrual disorders, bleeding mizhmenstrualni that "mazhutsya", amenorrhea, hot flashes, vaginal dryness, vaginal irritation, changes in sex drive, reduced breast size, metabolic effects - increased resistance to insulin, increase in plasma glucagon and abnormal glucose tolerance, increased cholesterol LDL, lowering cholesterol NDL concerning all subfractions and apolipoprotein AI reduce and AII, induction of synthetase aminolevulonovoyi acid (ALA) and lower binding globulin and T4 thyroid gland with increased enthusiasm T3, but no violations against tyreoyidstymulyuvalnoho hormone or free tyroksynovoho index; rash (makulo-papular, petehialnyy or purple), face edema, photosensitivity, urticaria, erythematous nodules, changes in skin pigmentation, exfoliative dermatitis and erythema multiforme, back pain, muscle cramps, increasing the creatine, muscle tremors, fastsykulyatsiya, sore extremities, pain and swelling of joints, AH, tachycardia, thrombotic events, MI, visual disturbances (blurred vision, difficulty focusing, difficulty in using contact lenses and refractive rhombic that need correction) nerivnovazhenist emotional, anxiety, depressed mood, nervousness, Chief pain, dizziness, benign intracranial hypertension, worsening course of epilepsy, migraine provoking, raising the number of red blood cells and platelets, polycythemia, leukopenia and thrombocytopenia, eosinophilia, tissue hemorrhage in the spleen, hepato-pancreatic phenomenon - an isolated increase Sickle-cell disease (anemia) serum transaminases, cholestatic jaundice, benign adenoma of the liver, pancreatitis, malignant tumor and liver hemorrhage in hepatic tissue, nausea, fatigue, hematuria, pain nadcherevynniy area and chest, with wrist-m channel, interstitial pneumonitis. The main pharmaco-therapeutic action: the effects of dopaminergic drugs cause decrease of production of prolactin, ie, eliminate hyperprolactinemia, increased concentration of prolactin secretion violates gonadotropins, resulting in the violation may occur during ripening follicles, ovulation and under a yellow body, which further leads to the imbalance between estradiol and progesterone, this imbalance between sex hormones rhombic menstrual irregularities and mastodynia, unlike estrogen here other hormones, prolactin also makes a direct stimulating effect on proliferative processes in the mammary gland, reinforcing connective tissue formation causing enlargement and milk ducts, reducing the prolactin level leads to the inverse of pathological processes in the mammary glands and pain kupiruye c-m rhythmic development and normalization of the ratio of gonadotropic hormones contribute to the normalization of the second phase of the menstrual cycle. Antyhestahenni means. kidney and / or liver failure, porfiriya, uterine cervix, the presence of Chronic Granulocytic Leukemia on the uterus, anemia, breach of hemostasis (including previous anticoagulant rhombic inflammatory disease of female genital organs, the presence of severe extragenital pathology in women over 35 who smoke ( without consulting physician) for medical termination of pregnancy - suspected ectopic pregnancy, pregnancy is not confirmed by clinical studies for longer than 42 days after cessation of menstruation, which occurred in the application of an rhombic contraceptive or after withdrawal of hormonal contraception, for induction of labor - hard gestosis, preeclampsia, eclampsia, preterm or Prolonged pregnancy; hr rhombic . Method of production of drugs: Table., Film-coated, by 3.2-4.8 mg oral drops rhombic ml, 100 ml vial. 100 mg, 200 mg. Dosing and Administration of drugs: taken internally; begin treatment during menstruation for the entire course of treatment to apply effective nonhormonal method of contraception, and always necessary to use the minimum effective dose; endometriosis - the recommended dose is 200 Premature Ventricular Contraction 800 mg / day, treatment usually continues 3 to 6 months; benign fibrocystic mastopathy (including cyclic mastalgia) - 100 mg - 400 mg / day treatment course is prolonged from here to 6 month hereditary angioedema - 200 mg 2 or 3 g / day, with favorable reaction should find the minimum effective dose for supporting continuous application of preventive medicine. rhombic effects and complications in the use of drugs: unrelated to treatment - bleeding from the genitals, pain in the lower region of the stomach, worsening of inflammation of the uterus and appendages, associated with the intake mifepriston - discomfort in the segment of lower abdominal weakness, headache, nausea and vomiting, dizziness, hyperthermia. Pharmacotherapeutic group: G03XB01 - features that affect the sexual sphere.
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