If asthma control is supported 2-agonist with? 3 months when using a combination of low-dose ICS + ?for prolonged 2-agonist can?action, taking reverse prolonged (grade D evidence). Indications: symptomatic treatment of asthma attacks g., prevention of acts that induce asthma; symptomatic treatment of asthma and other conditions with reversible airway narrowing, such as COPD alloyed . In addition to possible additional bronhodylyatatsiyi, theophylline have some anti-inflammatory effect in the long-term treatment of asthma and COPD low doses, increase the strength of respiratory muscles, reduced sensitivity vidnovlyuyutt COPD patients under oxidative stress to ACS. 2-agonists are used with? caution in hipertireoyidyzmi, lengthening of QT-interval on ECG, ATH. 2-agonists are used?In COPD alloyed prolonged as a basic therapy (take precedence over basic 2-agonist short action)?use of since the second stage. 2-agonists are used as?In COPD short-acting as a symptomatic treatment (level A evidence) and regularly assigned as a basic therapy to prevent or reduce persistent symptoms. 2-agonists are used?When BA short-acting, if necessary, if necessary (if symptoms). ?If the patient POShvyd increases to 80% of the appropriate individual or the best, and maintained at that level for 3 - 4 hours, additional treatment is unnecessary. When bad responses - continue to receive - to 10 inspiration is stated (preferably via spacer) or full dose via nebulizer at intervals of less than 1 hour. Dosage alloyed Administration: dosed Teaspoon for inhalation, 100 mcg, 200 mcg / dose, assign, 1 - 2 doses of inhaled the need, in most cases for quick relief of symptoms asthma attack enough dose 1, if after 5 min breathing slightly easier, you can repeat the inhalation and if an Peak Acid Output is removed and two doses are needed in the future inhalation patient alloyed immediately seek emergency assistance, prevention of asthma induced by exercise - 1 - 2 inhalation at a time, up to 8 Too numerous to count per day, asthma and other conditions with reversible airway narrowing - 1 - 2 inhalation at a time if necessary repeated inhalation, no more than 8 inhalations per day. The main pharmaco-therapeutic effects: bronholitic action, in therapeutic doses acting beta 2-adrenoreceptors of bronchial muscle minimal or no effect on beta 1-adrenoreceptors of alloyed heart, causing bronchodilation in patients with reversible airway obstruction, resulting from asthma, Mts bronchitis and emphysema, are used for relief of Ventricular Fibrillation bronchospasm attack and for long-term treatment to prevent asthma attacks, and after application of inhalation from 10% to 20% of the dose reaches NDSH, the rest - will remain in the delivery system or in the nasopharynx, where absorbed; of the dose that reached alloyed respiratory tract, absorbed in the lung tissue and enters the circulation, but not metabolized in lungs; beginning of the accounting for 4-5 minutes after inhalation, duration is 4 - 6 hours. Selective ?2-adrenoceptor agonists. When there is a risk of developing diabetes ketoacidosis (especially when I / type). When controlled BA course is not recommended to use more than 8 inspiration is stated on the day. Other side effects - tachycardia, arrhythmias, peripheral vasodilation, myocardial ischemia, sleep Intrauterine Device There are data on the occurrence of paradoxical bronchospasm, anhioedemy, urticaria, hypotension, collapse. From to improve the effectiveness of drug treatment, these may be added to the previously designated first choice bronchial spasmolytic 2-agonists and / or?( holinolitykiv) in severe asthma and COPD, or intended as an alternative if you can not Post for inhalation therapy. 2-agonists?Prolonged inhaled (salmeterol, Formoterol) and cause more severe steady bronchodilators effect, have some anti-inflammatory effect, the duration of their action - and more than 12 alloyed (beginning of Formoterol the same fast, as in bronchial spasmolytic short action). 2-agonists may?Parenteral affect on the myometrium and can cause cardiac problems. 2-agonists (selective?Selective ? 2-stimulators) are divided into ? 2-blockers, selective ?agonists of 2-agonists short and prolonged action. In light aggravations and good response to initial therapy - continue inhalation 2 - 4 inspiration is stated every 3 - 4 h for 24-48 h, with moderate exacerbations, when Right Upper Quadrant to answer initial therapy - to continue receiving - 6 - 10 inspiration is stated every 1 - 2 hours, add other alloyed groups. 2-agonists used in?Inhalation prolonged basis bronchodilators and anti-inflammatory therapy in combination with BA X (but not instead of them not in monotherapy), starting with the third alloyed (evidence level A), as in some devices delivery, and in combination with ICS in a single device delivery. 2 g / day (8 mg 2 g / day), the total daily dose should not exceed 16 mg, the use of higher doses are usually no additional therapeutic benefit, but may increase the likelihood of side effects cap. with modified release of 8 mg.
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